The opposite side of Sint Anna Bay – Otrobanda – wasn't developed until the beginning of the 18th century. However, there were many similarities to Punto along the waterfront. A quay was realised here by building up the natural bank. Some of the buildings were erected some dozens of metres from the waterside. Although Otrobanda's layout was also largely based on a rectangular street plan, its initial design was considerably more spacious. The buildings were much larger and stood on larger plots as well. Furthermore, the design of the houses included porticos and arcades from the onset and many of them had two floors. Baroque influences could be seen in Otrobanda as well. Some of the open character of the quarter was lost through constant condensing and a network of alleys with predominantly small, modest buildings developed behind the main streets.

The urban middle class as well as many of the working population lived in Otrobanda. During the course of the 19th century Otrobanda expanded northwards and uphill, thus reducing the building density and enabling similarities to the plantation houses from outside the city. The increasing importance of this quarter manifested itself, among other things, in the Queen Emma bridge, a pontoon bridge built in 1888. This pedestrian bridge over Sint Anna Bay still connects the quays opposite and the Punda and Otrobanda quarters. Sint Anna Bay, together with Punda and Otrobanda, is the heart of the section of town that has been designated as a World Heritage.